Jan 25, - Medications taken by a male can interfere with fertility in several different ways. Finally, some medications may affect the sperm directly. May 25, - Keeping sperm healthy: Drug-related measures to protect sperm. Stopping smoking; Minimising alcohol consumption; Avoiding anabolic steroids and other performance enhancing drugs; and. Avoiding marijuana, cocaine and other recreational drugs.Introduction to sperm, drugs · Smoking tobacco · Recreational drugs.