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Methenamine hippurate (dosage, 1 g twice daily) has been approved by the FDA for UTI prophylaxis. A recent Cochrane review concluded that methenamine. Oct 10, - Women whose recurrent UTIs are associated with sexual intercourse should be offered postcoital prophylaxis. This involves taking a single dose of an effective antimicrobial (eg, nitrofurantoin 50 mg, trimethoprim-sulfamethoxazole [TMP-SMX] 40/ mg, or cephalexin mg) after sexual intercourse.